研究成果

2017年度7月以降

加藤薫(産業技術総合研究所 バイオメディカル研究部門)

  1. Kijima, S. Staiger, C., Katoh, K.., Nagasaki, A., Ito, K., and Uyeda, T. (2018)  Arabidopsis vegetative actin isoforms, AtACT2 and AtACT7, generate distinct filament arrays in living plant cells. Sci Rep. in press
  2. Ito, N., Katoh, K., Kushige, H., Saito, Y., Umemoto, T., Matsuzaki, Y., Kiyonari, H., Kobayashi, D., Soga, M., Era, T., Araki, N., Furuta, Y., Suda, T., Kida, Y., and Ohta K. (2018) Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency. Sci Rep. 8, 1634 | DOI:10.1038/s41598-018-20057-1
  3. 加藤薫(2018) 超解像光学顕微鏡, 光技術動向調査報告書2017年度、(印刷中)
  4. Ohzono, T., Katoh, K., Wang, C., Fukazawa, A., Yamaguchi, S., and Fukuda, J. (2017) Uncovering different states of topological defects in schlieren textures of a nematic liquid crystal. Sci. Rep. 7, 16814 | DOI:10.1038/s41598-017-16967-1

木下タロウ(大阪大学)

  1. Nguyen, Thi Tuyet Mai*, Y. Murakami*, E. Sheridan*, S. Ehresmann, J. Rousseau, A. St-Denis, G. Chai, N. F. Ajeawung, L. Fairbrother, T. Reimschisel, A. Bateman, E. Berry-Kravis, F. Xia, J. Tardif, D. A. Parry, C. V. Logan, C. Diggle, C. P. Bennett, L. Hattingh, J. A. Rosenfeld, M. S. Perry, M. J. Parker, F. Le Deist, M. S. Zaki, E. Ignatius, P. Isohanni, T. Loennqvist, C. J. Carroll, C. A. Johnson, J. G. Gleeson, T. Kinoshita and P. M. Campeau. (2017) Mutations in GPAA1, encoding a GPI transamidase complex protein, cause developmental delay, epilepsy, cerebellar atrophy, and osteopenia. Am. J. Hum. Genet., 101:856-865.

  2. Liu, Y.-S., X.-Y. Guo, T. Hirata, Y. Rong, D. Motooka, T. Kitajima, Y. Murakami, X.-D. Gao, S. Nakamura, T. Kinoshita and M. Fujita. (2017) N-Glycan dependent protein folding and endoplasmic reticulum retention regulate GPI-anchor processing. J. Cell Biol., 217: 585-599.

  3. Hirata, T., S. K. Mishra, S. Nakamura, K. Saito, D. Motooka, Y. Takada, N. Kanzawa, Y. Murakami, Y. Maeda, M. Fujita, Y. Yamaguchi and T. Kinoshita. (2017) Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Nat. Commun., 9:405.

  4. 木下タロウ(2017)後天性突然変異で生じるGPIアンカー欠損赤血球と発作性夜間ヘモグロビン尿症、生化学、89(3):351-358.

  5. Colley, K. J., Varki, A. and Kinoshita, T.  (2017) Cellular Organization of Glycosylation. In Essentials of Glycobiology 3rd ed. Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A., Kinoshita, T., Packer, N.J., Prestegard, J., Schnaar, R., Seeberger, P. (eds.), p41-49. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
    https://www.ncbi.nlm.nih.gov/pubmed/28876808

  6. Schnaar, R. L. and Kinoshita, T.  (2017) Glycosphingolipids. In Essentials of Glycobiology 3rd ed. Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A., Kinoshita, T., Packer, N.J., Prestegard, J., Schnaar, R., Seeberger, P. (eds.), p125-135. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
    https://www.ncbi.nlm.nih.gov/pubmed/28876845

  7. Ferguson, M. A. J., Hart, G. W. and Kinoshita, T.  (2017) Glycosylphosphatidylinositol anchors. In Essentials of Glycobiology 3rd ed. Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A., Kinoshita, T., Packer, N.J., Prestegard, J., Schnaar, R., Seeberger, P. (eds.), p137-150. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
    https://www.ncbi.nlm.nih.gov/pubmed/28876821

  8. Freeze, H. H., Kinoshita, T.  and Schnaar, R. L.  (2017) Genetic disorders of glycan degradation. In Essentials of Glycobiology 3rd ed. Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A., Kinoshita, T., Packer, N.J., Prestegard, J., Schnaar, R., Seeberger, P. (eds.), p553-568. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
    https://www.ncbi.nlm.nih.gov/pubmed/28876818

  9. Freeze, H. H., H. Schachter and Kinoshita, T.  (2017) Genetic disorders of glycosylation. In Essentials of Glycobiology 3rd ed. Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A., Kinoshita, T., Packer, N.J., Prestegard, J., Schnaar, R., Seeberger, P. (eds.), p569-582. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
    https://www.ncbi.nlm.nih.gov/pubmed/28876812

  10. Freeze, H. H., Kinoshita, T.  and Varki, A. (2017) Glycans in acquired human diseases. In Essentials of Glycobiology 3rd ed. Varki, A., Cummings, R.D., Esko, J.D., Stanley, P., Hart, G.W., Aebi, M., Darvill, A., Kinoshita, T., Packer, N.J., Prestegard, J., Schnaar, R., Seeberger, P. (eds.), p583-595. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
    https://www.ncbi.nlm.nih.gov/pubmed/28876835

  11. Kohashi, K., A. Ishiyama, S. Yuasa, T. Tanaka, K. Miya, Y. Adachi, N. Sato, H. Saitsu, C. Ohba, N. Matsumoto, Y. Murakami, T. Kinoshita, K. Sugai and M. Sasaki. 2017. Epileptic apnea in a patient with inherited glycosylphosphatidylinositol anchor deficiency and PIGT mutations. Brain Dev., 2017 Jul 17. pii: S0387-7604(17)30174-2. PMID: 28728837

片桐豊雅(徳島大学)

  1. Daizumoto, K., Yoshimaru, T., Matsushita, Y., Fukawa, T., Uehara, H., Ono, M., Komatsu, M., Kanayama, H., and Katagiri, T. (2018) A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer. Cancer Res. in press.
  2. Miyagawa, Y., Matsushita, Y., Suzuki, , Komatsu, M., Yoshimaru, T., Kimura, R., Yanai, A., Honda, J., Tangoku, A., Sasa, M., Miyoshi, Y., and Katagiri, T. (2018) Frequent downregulation of LRRC26by epigenetic alterations is involved in the malignant progression of triple-negative breast cancers. Int J Oncol. in press.

中野明彦(東京大学、理化学研究所)

  1. Minamino, N., Kanazawa, T., Era, A., Ebine, K., Nakano, A., and Ueda, T. RAB GTPases in the basal land plant Marchantia polymorphaPlant Cell Physiol. in press.
  2. Tanabashi, S., Shoda, K., Saito, C., Sakamoto, T., Kurata, T., Uemura, T., and Nakano, A. A missense mutation in the NSF gene causes abnormal Golgi morphology in Arabidopsis thalianaCell Struct. Funct. in press.
  3. Takemoto, K., Ebine, K., Askani, J. C., Goh, T., Schumacher, K., Nakano, A., and Ueda, T. Distinct sets of tethering complexes, SNARE complexes, and Rab GTPases mediate membrane fusion at the vacuole in Arabidopsis. Proc. Natl. Acad. Sci. U. S. A. in press.
  4. Suda, Y., Kurokawa, K., and Nakano, A. Regulation of ER-Golgi transport dynamics by GTPases in budding yeast. Frontiers Cell Dev. Biol. in press.
  5. Suda, Y., Tachikawa, H., Inoue, I., Kurita, T., Saito, C., Kurokawa, K., Nakano, A., and Irie, K. Activation of Rab GTPase Sec4 by its GEF Sec2 is required for prospore membrane formation during sporulation in yeast Saccharomyces cerevisiae. FEMS Yeast Res. in press.
  6. Yamagami, A., Saito, C., Sakuta, M., Shinozaki, M., Osada, H., Nakano, A., Asami, T., and Nakano, T. Brassinosteroids regulate vacuolar morphology in root meristem cells of Arabidopsis thaliana. Plant Signal. Behav. in press.
  7. Sanchez-Rodriguez, C., Shi, Y., Kesten, C., Zhang, D., Sancho-Andrés, G., Ivakov, A., Lampugnani, E. R., Sklodowski, K., Fujimoto, M., Nakano, A., Bacic, A., Wallace, I. S., Ueda, T., van Damme, D., Zhou, Y., and Persson, S. The cellulose synthases are cargo of the TPLATE adaptor complex. Mol. Plant in press.
  8. Ito, Y., Uemura, T., and Nakano, A.(2018). Golgi Entry Core Compartment functions as the COPII-independent scaffold for ER-Golgi transport in plant cells.  J. Cell Sci. 131:jcs203893.
  9. Kobayashi, K., Suemasa, F., Sagara, H., Nakamura, S., Ino, Y., Kobayashi, K., Hiramatsu, H., Haraguchi, T., Kurokawa, K., Todo, T., Nakano, A., and Iba, H. (2017) MiR-199a inhibits secondary envelopment of herpes simplex virus-1 through the downregulation of Cdc42-specific GTPase activating protein localized in Golgi apparatus. Sci. Rep. 7, 6650
    https://www.ncbi.nlm.nih.gov/pubmed/28751779
  10. Yamagami, A., Saito, C., Nakazawa, M., Fujioka, S., Uemura, T., Matsui, M., Sakuta, M., Shinozaki, K., Osada, H., Nakano, A., Asami, T., and Nakano, T. (2017) Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation. Sci. Rep. 7, 5739
    https://www.ncbi.nlm.nih.gov/pubmed/28720789

齊藤達哉(徳島大学)

  1. Takahama M, Akira S, and Saitoh, T. (2017) Autophagy limits activation of the inflammasomes. Immunol Rev.  doi:10.1111/imr.12613, in press

  2. Takahama, M., Fukuda, M., Ohbayashi, N., Kozaki, T., Misawa, T., Okamoto, T., Matsuura, Y., Akira, S., and Saitoh, T. (2017) The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses. Cell Rep. 20, 2944-2954.

  3. 髙濵充寛,齊藤達哉 (2017) インフラマソーム. 炎症と免疫 25, 94-96.

  4. 髙濵充寛,齊藤達哉 (2017) オートファジー. 周産期医学 47, 1513-1520.

  5. 渋谷周作, 齊藤達哉, 吉森保 (2017) オートファジーと生体防御応答. 実験医学増刊 The オートファジー 研究者たちの集大成が見える最新ビジュアルテキスト 35, 144-150.

  6. Misawa, T., Takahama, M., and Saitoh, T. (2017) Mitochondria–Endoplasmic Reticulum Contact Sites Mediate Innate Immune Responses. In: Tagaya, M., Simmen, T. (eds) Organelle Contact Sites. Adv. Exp. Med. Biol., 997, 187-197, Springer, Singapore
  7. 齊藤達哉. (2017) 尿酸塩結晶によるインフラマソーム活性化と痛風性関節炎. 尿酸と血糖 3, 6-9
  8. 齊藤達哉. (2017) 痛風関節炎の発症機序. カレントテラピー 35, 61-65

花田賢太郎(国立感染症研究所)

  1. Sakuma, C., Sekizuka, T., Kuroda, M., Kasai, F., Saito, K., Ikeda, M., Yamaji, T., Osada, N., and Hanada, K. Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate. Sci. Rep. in press (CS and TS are co-first authors. NO and KH are co-correspondence)

  2. Shimasaki, K., Watanabe-Takahash, M., Umeda, M., Funamoto, S., Saito, Y., Noguchi, N., Kumagai, K., Hanada, K., Tsukahara, F., Maru, Y., Shibata, N., Naito, M., and *Nishikawa, K. (2017) The pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy. Gene-to-Cell in press
  3. Otsuki, N., Sakata, M., Saito, K., Okamoto, K., Mori, Y., *Hanada, K., and *Takeda, M. Both sphingomyelin and cholesterol in the host cell membrane are essential for Rubella virus entry. J Virol. in press. (selected as Spotlight, a highlighted article of the issue)
  4. Hanada, K. (2017) Ceramide transport from the endoplasmic reticulum to the trans Golgi region at organelle membrane contact sites.  In: Tagaya, M., Simmen, T. (eds) Organelle Contact Sites. Adv. Exp. Med. Biol., 997, 69-81, Springer, Singapore

 

矢木宏和(名古屋市立大学)

  1. Yagi, H., Yan, G., Suzuki, T., Tsuge, S., Yamaguchi, T., and Kato, K. (2017) Lewis X-carrying neoglycolipids evoke selective apoptosis in neural stem cells. Neurochem Res in press
  2. Yanaka, S., Yamazaki, T., Yogo, R., Noda, M., Uchiyama, S., Yagi, H., and Kato, K. (2017) NMR Detection of Semi-Specific Antibody Interactions in Serum Environments. Molecules 22, E1619
  3.  Yogo, R., Yanaka, S., Yagi, H., Martel, A., Porcar, L., Ueki, Y., Inoue, R., Sato, N., Sugiyama, M., and Kato, K. (2007) Characterization of conformational deformation-coupled interaction between immunoglobulin G1 Fc glycoprotein and a low-affinity Fcγ receptor by deuteration-assisted small-angle neutron scattering. Biochem Biophys Rep 16, 1-4
  4. Yagi, H., Tateno, H., Hayashi, K., Hayashi, T., Takahashi, K., Hirabayashi, J., Kato, K., and Tsuboi, M. (2017) Lectin microarray analysis of isolated polysaccharides from Sasa veitchii. Biosci Biotechnol Biochem 81, 1687-1689
  5. 矢木宏和、加藤晃一 (2017) NMRを利用して糖タンパク質糖鎖の構造動態と相互作用を観る. 医学のあゆみ 262, 467-473

森和俊(京都大学)

  1. Ishikawa, T., Kashima, M., Nagano, A. J., Ishikawa-Fujiwara, T., Kamei, Y., Todo, T. and Mori, K. (2017) Unfolded Protein Response Transducer IRE1-mediated Signaling Independent of XBP1 mRNA Splicing Is Not Required for Growth and Development of Medaka Fish. eLife, 6, e26845.

田村康(山形大学)

  1. Tamura, Y. and Endo, T. (2017) Role of Intra- and Inter-mitochondrial Membrane Contact Sites in Yeast Phospholipid Biogenesis. In: Tagaya, M., Simmen, T. (eds) Organelle Contact Sites. Adv. Exp. Med. Biol., 997, 121-133, Springer, Singapore

細谷孝充(東京医科歯科大学)

  1. Nishiyama, Y., Hazama, Y., Yoshida, S., and Hosoya, T. (2017) Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents. Org. Lett. 19, 3899-3902

名黒功(東京大学)

  1. Hattori, K., Ishikawa, H., Sakauchi, C., Takayanagi, S., Naguro, I., and Ichijo, H. (2017) Cold stress-induced ferroptosis involves the ASK1-p38 pathway. EMBO Rep. in press.
  2. Kamiyama, M., Shirai, T., Tamura, S., Suzuki-Inoue, K., Ehata, S., Takahashi, K., Miyazono, K., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I., and Ichijo, H. (2017) ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets. Cell Death Differ. in press.

尾野雅哉(国立がん研究センター研究所)

  1. Kagami, Y., Ono, M., and Yoshida, K. (2017) Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis. Sci Rep 7, 5583
  2. 尾野雅哉 (2017) パラフィン包埋標本を用いたプロテオーム解析. 病理と臨床. 35(7), 622-627

金川基(神戸大学)

  1. Kamizaki, K., Doi, R., Hayashi, M., Saji, T., Kanagawa, M., Toda, T., Fukada, SI., Ho, HH., Greenberg, ME., Endo, M., Minami, Y. (2017) The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle. J. Biol. Chem.in press (jbc.M117.785709. doi:10.1074/jbc.M117.785709)